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The zipFv also demonstrated greater stability in serum and the same protective rate as RIG against challenge with a standard rabies virus (CVS-24) in mice.
For Fab094-CPNPs, 8 IU/kg antibody plus vaccine provided a protective rate that was equal to that with 20 IU/kg HRIG plus vaccine.
This protective rate varied from 35%to40%40 % according to different supplementation times.
Thus, a lower probability of exposure amongst the cases may lead to a biased protective rate ratio.
However, when the female mice were immunized with 0.01 μg of inactivated vaccine, the protective rate of offspring was 85.7% (p < 0.05) (Table 3 and Figure 1C).
A combination of t1/2 = 15.2 min for human stomach emptying (mean value from three studies with water) and a more protective rate of t1/2 = 7 min predicts that 22.2% Cr VI) will reach the duodenum.
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In addition, these vaccines induce antibodies primarily to the viral HA and are efficacious in healthy adults, but display lower protective rates in high-risk groups (e.g., the elderly) and may be poorly immunogenic in young children.
As shown in Table 3, when the female mice were immunized with 1.0 μg and 0.1 μg of inactivated vaccine and their offspring with HA DNA, the protective rates of offspring were 50% and 42.8% respectively (p > 0.05).
A mathematical analysis of these results allowed a reliable protective rating in Spain, taking into account the differences among subjects included in the primovaccinated or booster groups and in the catch-up policy.
In developed countries, the vaccination schedule against hepatitis B has been followed well in the routine practices and the protective efficiency was 90 100% in infants born to HBV carrier mothers, as high as the protective rates achieved in the clinical trials [ 9- 12].
For each vaccination group, geometric mean titers (GMTs), protection rate (percentage of volunteers with protective PRNT50 titers), and response rate were calculated.
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