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Using this model we can further study the pathophysiology of MTX-induced cognitive dysfunction and test protective interventions.
This will have three major implications: (i) to design novel intervention studies that aim to strengthen protective factors and cognitive reserve, (ii) to provide an in vivo test system for the mode of action of potentially protective interventions, and (iii) to serve as a secondary endpoint for the effectiveness of interventions.
Therefore, as in our study, protective interventions should be started after the initiation of global reperfusion, when significant damage has already occurred.
Mathematical modelling has demonstrated that the use of a pre-pandemic vaccine before or soon after the onset of a pandemic, in combination with other protective interventions, can be highly effective in reducing the clinical attack rate by as much as 75% [7], [8].
Therefore, attention to disease resistance mechanisms may lead to protective interventions for threatened amphibian species.
Clinically, endothelial protective interventions would be expected to attenuate the sepsis-induced hypocoagulability.
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We suggest that sevoflurane in addition to hypothermia may be considered as a protective intervention in the post-resuscitation period.
Preconditioning refers to application of a protective intervention prior to ischemia.
Thus, although obesity might induce some benefit, these very effects might also render hearts resistant to further protective intervention.
The research will use an extended version of the TPB [ 15] to develop and test the utility of a sun protective intervention derived from this approach.
Therefore, OO supplementation is a potential candidate for use as a protective intervention against the adverse vascular effects of PM exposure.
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