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However, neutrophils are generally considered to be bone protective in the context of periodontal disease-induced bone loss (for review [ 70, 71]).
Notably, the known beta cell anti-apoptotic factors, insulin and IGF2 [ 14, 37], were protective in the context of lipotoxicity more consistently relative to the other stresses.
For example, semaphorin4A (SEMA4A) was toxic to islet cells in the serum-free baseline and serum-free 20 mmol/l glucose conditions, but protective in the context of lipotoxicity.
Although high expression of E2F1 in VHL-defective renal cancer is associated with senescence and has been suggested to be protective in the context of renal cancer, caution is warranted in designating E2F1 as oncogene or tumor suppressor gene for which clearly more extensive investigation is required.
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Contrary to these reports, a recent study found that myofibroblasts may serve a protective role in the context of pancreatic cancer as depletion of myofibroblasts and fibrosis in a mouse model of pancreatic ductal adenocarcinoma leads to a more invasive cancer cell phenotype and reduced survival [40].
Clinical and experimental studies suggest that the probiotic mixture VSL#3 has protective activities in the context of inflammatory bowel disease (IBD).
Moreover, some cytoadherence phenotypes, such as adhesion to CD36, have been associated with uncomplicated malaria [22], [24], [29], suggesting a protective role in the context of severe disease [30], [31].
Hypercapnic acidosis exhibits more modest protective effects in the context of more clinically relevant tidal stretch [ 31].
Here, we speculate on the potential utility of EPO as a protective cytokine in the context of acute critical illness and suggest key parameters required for a proof-of-concept clinical study.
How participants may prevent or take protective measures in the context of both CHD and distress/depression The views of participants on medication for both their heart condition and depression The interviews will be audio-taped and transcribed verbatim.
We conclude that reliability analysis is useful to test hypotheses about putative risk and protective factors in the context of descriptive research, perhaps leading to caution as in the present study.
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