This meta-analysis suggests that GDF5 rs143383 polymorphism is highly associated with the susceptibility to knee OA with protective associations for the C allele and CC genotype across different populations.
Such associations had counterparts in the late Hellenistic world, just as they have parallels in the voluntary protective associations formed in the 19th and 20th centuries whenever official institutions of protection were either chronically or temporarily deficient.
Protective associations with priapism and leg ulcers are consistent with effects on bioavailable NO [1], [2].
IFIH1 is causal in type 1 diabetes based on the protective associations of four rare variants, where the derived alleles are predicted to reduce gene expression or function.
A previous study in adults found protective associations of carriers of minor alleles of the FADS1 FADS2 gene cluster with allergic rhinitis and atopic eczema [6].
We propose that the protective associations detected previously for the HCP5-G allele [27] are perhaps due to a specific set of B*57-containing genotypes, i.e., those that are also homozygous for the HLA-C5'-C allele (Figure 4, group 3).
Among women enrolled from 1997 2001, the number of SP IPTp doses was associated with protection against placental parasitemia, maternal anemia and LBW, and with increases in mean maternal hemoglobin levels and birth weights, whereas from 2002 onwards, these protective associations were not found (Table 3).
It is known that IgG responses to AMA1 are acquired rapidly in early life, as mentioned above, and most sero-epidemiological studies that have revealed anti-malarial protective associations for anti-AMA1 IgG have included children below the age range of those in our study, possibly, therefore, offering an explanation for the different outcomes [28], [31], [35], [38], [41].
Significant protective associations were observed among children with higher intake of bean-curd foods and vegetables.
In the fully adjusted models, truncation of the sample significantly increased protective associations observed among men.
However, subjectively assessed dampness or mold has not shown protective associations, even in infants.
