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A versatile conjugatable/bioreduction-responsive protecting group for phosphodiester moieties was designed, synthesized and incorporated into oligonucleotide strands.
PLGA-b-PMLGSLG was synthesized via a diblock copolymer precursor consisting of poly(γ-tert-butyl-l-glutamate) (PtBuLG) and PMLGSLG blocks, with the tert-butyl group as a mild acid-labile protecting group for the carboxylic acid.
The site-specific DTPA conjugation was facilitated by using a highly acid-labile 4-methyltrityl (Mtt) protecting group for the target site of the bioactive peptide during the solid-phase synthesis.
To limit the possible side reactions, a suitable protecting group for the hydroxamic acid was studied.
Wang and co-workers developed a photoremovable protecting group for carbonyl compounds based on trityl photochemistry.
The bromonitroindoline 120 was used in an early example of peptide synthesis as a protecting group for the C-terminus.
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This strategy stands for a sustainable synthesis and enhanced resolution by means of alternative protecting groups for the amino/acid functionalities than that previously reported.
Four different protecting groups for position 7 of chrysin have been compared, and found to follow the order of interest Bz>MOM>TBDPS>MEM.
Therefore various other protecting groups for the hydroxamate were investigated.
We used base-labile protecting groups for the amino functions and 5′-OH group.
The functional diversity of aptamers enables their use for diagnostic and analytical detection; as therapeutics, drug targets, and drug delivery vehicles; as noncovalent chemical protecting groups; for intracellular imaging and scaffolding; for enzyme and strain engineering; and for gene regulation.
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