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In vivo, ecSOD has been implicated in protecting endothelial function in various cardiovascular diseases by controlling the levels of extracellular O2− and nitric oxide (NO) bioactivity in the vasculature [14].
In the swine heart, nicorandil reduced myocardial no-reflow after ischemia reperfusion by protecting endothelial function [ 18].
In addition, the anti-oxidant effect of curcumin on protecting endothelial function against ROS damage may be partially attributed to the hypoglycemic effect of curcumin.
The ability of GLP-1 in protecting endothelial function seems to depend on the level of glycemia, a phenomenon already described for insulin secretion.
As for insulin secretion, the ability of GLP-1 in protecting endothelial function seems to be dependent on the level of glycemia (5).
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Our findings would shed a novel insight into the potential mechanism by which diosgenin protected endothelial function against inflammatory insult.
This study was designed to determine if a brief 3-h exposure to metformin protects endothelial function against the effects of hyperglycaemia.
In addition, it is unclear whether nicorandil, a KATP channel opener, used as hyperpolarizing cardioplegia or added in hyperkalemic cardioplegic solution may protect endothelial function during cardiac surgery.
Furthermore, DPP-4 inhibitors protect endothelial function through a GLP-1-dependent mechanism.
In experimental studies, ivabradine has been shown to protect endothelial function.
Glucagon-like peptide 1 (GLP-1) has antioxidant properties, and evidence suggests that it protects endothelial function.
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