Sentence examples for protecting cohesion from inspiring English sources

The Shugoshin (Sgo) protein family helps to ensure proper chromosome segregation by protecting cohesion at the centromere by preventing cleavage of the cohesin complex.

The correlation between the effects of mutations on binding PP2A in vitro and on protecting cohesion in vivo implies that the interaction of PP2A with Sgol2's coiled coil is essential for protecting cohesin from separase at the first meiotic division.

These genetic tests reveal that low, but detectable, levels of MEI-S332 at the centromere can protect cohesion.

Lee et al had proposed that Sgo2 alone plays a predominant role in protecting centromeric cohesion in meiosis I in oocytes, whereas Sgo1 is mostly, if not entirely, dispensable for this function [21].

The former is essential for protecting centromeric cohesion from the prophase pathway during mitosis [ 20] while the latter protects it from separase during meiosis [ 21].

SGO proteins therefore regulate both kinetochore structure/orientation in addition to their role in protecting centromere cohesion during prophase of mitosis and in meiosis I divisions.

Sgol2's coiled coil domain binds PP2A in vitro (Xu et al., 2009) but whether this is vital for protecting centromeric cohesion is not known.

DOI: http://dx.doi.org/10.7554/eLife.01133.003 To investigate whether association of PP2A with Sgol2's coiled coil is necessary for protecting centromeric cohesion, we compared the effect of the mutations on PP2A's co-localization with Sgol2 at kinetochores with their effect on the maintenance of cohesion after oocytes have undergone the first meiotic division.

Why is it important to protect centromeric cohesion during meiosis I? Cohesin-mediated sister chromatid cohesion is essential for proper attachment of sister kinetochores to microtubules emanating from the opposite poles.

Second, the stated premise of the law--to protect unit cohesion and combat effectiveness--is not supported by any scientific studies.

When he and I talked about the military's ban on gay, lesbian, and bisexual people serving openly, he described it as an embarrassment to the armed forces that couldn't be justified, and easily dismissed the idea that it was meant to protect "unit cohesion".