In the winters, the temperature of the lakes moderates the harsh cold, protecting dormant vines.
Like the normal tissue stem cells, multidrug resistance (MDR) transporters protect dormant cancer stem cells, and MDR is constitutively expressed at stable and high levels in T-ICs with stem-cell like features.
6, 33, 34 GRP78 has also been shown to protect dormant tumor cells from chemotherapy-induced apoptosis, mainly through suppressing activation of the apoptotic pathway.
Importantly, as well as activating mechanisms that preserve genome integrity and protect dormant origins in this tissue, the timing and expression of regulators such as p21 and p16 must be appropriately controlled.
In winter, the lakes almost never freeze, moderating harsh cold to protect the dormant vines, while in summer they air-condition the vineyards.
These genes encode small peptides, which are thought to protect the dormant beetle against microbial infections in diapause.
Meristems of woody perennials from temperate climates go through the cold season in a dormant stage, protected into specialized structures named buds.
It is also possible that the mRNAs of glycolytic genes, if bound to ribosomes or accumulated in P-bodies, are protected from degradation in the dormant spore and therefore enriched.
Protected by the cyst wall, however, the dormant contents of the cyst can survive for weeks.
Our results therefore suggest that HSCs, in particular the dormant subpopulation, represent an important population that is highly protected and only activated after more severe damage than done by these four damage-optimized regimens.
