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The adoptive transfer of CD4+CD25+Foxp3+ regulatory T cells (Tregs) in murine models of allogeneic hematopoietic cell transplantation (HCT) has been shown to protect recipient mice from lethal acute graft-versus-host disease (GVHD) and this approach is being actively investigated in human clinical trials.
After this treatment, we found that the exosomes harvested from oxidative stress lose their ability to protect recipient cells from oxidative stress.
In contrast, IL-17-producing Th cells recognising the same myelin autoantigen, which produce IL-17 together with IL-10, IL-22, and CCL20, are unable to cause disease and even protect recipient mice from the pathogenic effect of the aforementioned IL-17 producers [ 5].
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To protect recipients from prosecution, none of the money is paid in cash to people in Cuba.
They can also protect recipients from themselves, if they are too young to make good decisions, or from others, say a former spouse who maintains control over your children's finances.
Majority of HSC-induced antigen-specific CD8+ T cells display central memory phenotype, efficiently kill target cells in vivo, and protect recipients against tumor growth in a preventive setting.
To determine whether the HS-PCs mobilized through SHIPi treatment retained functional stem cell capabilities, we evaluated the capacity of peripheral blood from SHIPi treated donors to protect recipients from a lethal dose of radiation.
In the last few years, identification of tumour-associated antigens (TAAs) (Jäger et al, 2001) has prompted the development of different strategies for antitumour vaccination, aimed at inducing specific recognition of TAA-derived peptides in order to elicit a persistent immune memory that may eliminate residual tumour cells and protect recipients from relapses (Bocchia et al, 2000).
In contrast, adoptively transferred cells isolated from the lymph nodes of untreated mice protected recipient mice against challenge (Fig 2D).
Furthermore it was elegantly demonstrated by means of an adoptive transfer model that these Th2-differentiated cells protected recipient mice from developing the disease.
Finally, adoptive transfer of iLN cells from control immunized mice protected recipient naïve mice against PyWT sporozoite challenge, but the iLN cells from CD11c DC-depleted immunized mice failed to do so (Fig 3C).
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