We have previously demonstrated the presence of both TCTP mRNA and protein in prostatic tissue, in prostate cancer cell lines and in the prostatic fluid [ 18], suggesting specific roles for the protein such as apoptosis and control of sperm functions.
It would thus be interesting to investigate the eventual oncosuppressive role of the Men1 gene in prostatic cells in humans in the future.
In conclusion, the data presented herein show that the Rho signalling is involved in TEM in prostatic cancer in vitro.
Our findings therefore call for a detailed investigation of 4.1N expression and function in prostatic cells in future studies.
Here, seven genes; OPRK1, OR51E1, OR51E2, GPR160, NPY, CHRM1 and EDG7 displayed increased expression in prostatic samples in comparison to other tissue types [Additional file 5].
Fifty eight cases showed higher expression level of MIC-1 gene in cancerous prostatic tissues in comparison with noncancerous tissues.
The cells with these properties showed a higher efficiency to generate prostatic tissue in an in vivo reconstitution assay [ 48].
PSA is synthesized in normal prostate tissue, benign prostatic hypertrophy, and in prostate cancer.
Chronic prostatitis, being the most common diagnosis, was found in association to benign prostatic tissue in 86% of the samples, followed by 7% in hyperplasic prostatic tissue, 5% atrophic tissue, and finally accompanied by prostatic infarct in 2%.
In non-tumoural prostatic epithelium in general, no expression was seen (A), although some randomly distributed areas of weak positivity were noted (B).
