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The BPH rats displayed an increase in prostate weight, prostatic index with increased testosterone and DHT levels in both the serum and prostate, and increased serum PSA levels.
Prostate weight, prostatic index, and the testosterone and dihydrotestosterone (DHT) levels in serum and prostate, and the serum prostate specific antigen (PSA) levels were measured; prostate tissues were taken for histopathological examination; and serum biochemical analysis was also performed.
GTW treatment at both doses resulted in significant reductions in prostate weight, prostatic index, testosterone and DHT levels in both the serum and prostate, and serum PSA levels, compared with BPH group.
Compound 19 reduced the prostate weight of rats by 53.8%.
We first examined the statistical power of the studies to detect a positive effect on prostate weight.
In vivo 5a-reductase inhibitory evaluation of 16a also showed a more significant reduction effect (p < 0.001) in rat prostate weight than epristeride.
The in vivo study of IT-14 exemplified its promising action by reducing the prostate weight to the body weight ratio in prostate hyperplasia animal models.
A series of novel 2- 1H-indol-2-yl -propan-2-ols 2- 1H-indol-2-yl -propan-2-ols 2- 1H-indol-2-yl -propan-2-ols 2- 1H-indol-2-yl -propan-2-ols 2- 1H-indol-2-yl -propan-2-ols 2- 1H-indol-2-yl -propan-2-ols 2- 1H-indol-2-yl -propan-2-ols 2- 1H-indol-2-yl -propan-2-ols
The lower dose of CBZ (100 mg/kg) evaluated in the Hershberger test increased prostate weight compared to control group but did not alter the weight of other testosterone-dependent tissues.
The absolute dorsolateral prostate weight was increased in the 200 and 750 ppm dose groups only in the F1 PND50 rats, however, no significant effects were observed in other male reproductive organs.
Race and prostate weight as independent predictors for biochemical recurrence after radical prostatectomy.
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