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This process can lead to a loss of normal prostate functioning, characterized by excessive cell proliferation, inflammatory cell infiltration, and a loss of apoptosis, which in essence is a form of 'remodeling' that can permanently alter the prostate 'architecture.' Although BPH is largely confined to prostate abnormalities, a number of secondary degenerative changes can take place in the bladder.
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Herbal Groups had been running a "Prostate Health Blog," which published items about prostate function with promotions for the Prostalex product.
On the other hand, ESR2 is thought to be an important regulator of prostate function [14], especially as a potential "brake" to androgen-driven proliferation [13].
Zinc is a marker of prostate function [ 11].
Seminal vesicles and prostate function are important for chromatin stability [ 41].
On the other hand, retinoid is essential for normal prostate function [ 7, 27, 28] and exhibits anti-proliferative and chemopreventive efficacy in experimental prostate carcinoma [ 8- 10].
Androgen is essential for normal prostate function, but has also been implicated in the pathogenesis and neoplasia of prostate cancer [ 1, 2, 26].
This small amount of nontesticular androgen has a minimal impact on prostate function in physiologically normal males (Partin and Rodriguez 2002).
Here a key question is: what are the selective advantages conferred by the alterations in prostate function that eventually lead to BPH?
AcP10 could be such an element, and AcP10-expressing cells could have a distinct identity and set of properties, perhaps related to prostate function or development.
Androgen, a sex hormone that stimulates and maintains masculine characteristics, is a necessary component in normal prostate function that can also encourage the survival and growth of prostate cancer.
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