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While patients in our trial had relatively early disease (mean disease duration 3.4 years), we prospectively elected to enroll 10 patients with later disease (4 10 years), appreciating that this subgroup is also in need of better therapies.
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The data were collected prospectively for 84 weeks from 56 MS patients who elected natalizumab treatment.
Patients that elected to proceed with treatment were informed that data would be collected prospectively as part of a research project.
We prospectively studied 66 consecutively selected patients who had type 2 diabetes and a BMI of 30 34.9 kg/m, who elected to undergo RYGB.
As headache frequency and intensity were prospectively obtained from daily diaries, and the validity of headache data recalled over three months is questionable [59], we elected to not report these data here.
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