Prospective topics of further experimental and theoretical research in this area are outlined.
Besides the description of different fault diagnosis methods, a number of prospective research topics are outlined.
Trial inclusion criteria were: titles/abstracts relevant to topic; prospective 2-arm (or more) clinical study design.
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To date there have been no randomized, prospective studies on this topic.
The development of "de novo" MOH in patients overusing analgesics would establish this causative relationship, however, prospective studies on that topic are missing.
Jeung et al. conducted the only prospective study on this topic and found no difference between laparoscopically sutured interrupted figures-of-eight versus knotted double-layer running sutures (1.6 and 0.8 %, respectively) [5].
In a recent study by Hombach et al. [10] that included 141 DCM patients, midwall myocardial LGE was not an independent prognostic factor, stressing the need for large prospective studies on this topic [10].
Therefore, prospective studies on this topic are warranted; these are currently being planned.
In addition, prospective studies on this topic are very limited in Chinese populations.
