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In conclusion, in this prospective, relatively large cohort study of autoantibody-positive individuals at risk of developing RA, we confirmed that there was no clearcut synovial inflammation before the development of clinically apparent arthritis.
Much of what is known about the prevalence of liver disease in ATD and its outcome comes from a prospective, relatively unbiased study started in Sweden in the 1970s (Piitulainen et al., 2005; Sveger, 1976).
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Previous studies have mostly been prospective and relatively small.
Strengths of our study include its prospective design, relatively large size and complete follow-up.
The strengths of this study include the prospective design, relatively large cohort of diabetes patients and controls and different surrogate markers of atherosclerosis.
The strengths of the present study include its prospective design, relatively large patient numbers and detailed baseline assessments in each Phase.
Strengths of this study include its prospective design, relatively large sample size, long-term follow-up, large number and adjudication of CVD events, complete follow-up, and the ability to evaluate many potential confounders.
The sample size for the prospective study was relatively small and the cases of incident T2DM were limited.
We were not able to detect any associations to these risk factors, which may be caused by the fact that our prospective cohort included relatively few mothers who exhibited these risk factors.
This means that the sample size of most of the prospective studies is relatively small.
It was prospective with a relatively large sample size, involving a broad range of clinical presentations and diagnoses.
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