Sentence examples for prospective predictions from inspiring English sources
The data and references used in the prospective predictions can be found in Supplementary Table S2. Figure 2i shows the predicted and observed time course for the change from baseline in 4βHC following administration of carbamazepine (CYP3A4 inducer) for 24 weeks.
Based on the elucidated PKPD characteristics exhibited by a novel drug and the kinetics of the investigated biomarker, prospective predictions can be made for the drug response under new conditions; translating from the preclinical arena to the clinical setting, from the healthy volunteer to the patient, or from an adult to an elderly or a child.
In prospective predictions against seven enzymes, a substrate was identified for five.
Specific examples of successful prospective predictions of human PK using PBPK modeling can be found in the literature.
In a cross-sectional study like INTERHEART, the outomes are not entirely equivalent to the prospective predictions of death from MI or CHD.
This is because the prospective predictions are not suitable for creating predictions of (delayed) sensory input at the thalamic or cortical level.
The prospective prediction models had lower predictive R-squares than the concurrent prediction models.
Similar to the concurrent prediction models, the prospective prediction model which combined ADGs and Rx-MGs had a predictive R-square (0.382) that was higher than those using either ADGs or Rx-MGs.
Collectively, these non-physical modeling assumptions sharply limit the utility of widely used QSAR approaches for prospective prediction of ligand activity.
The enhanced levels of accuracy obtained with the SVR combined with PCA based calibration models open up avenues for prospective prediction in coal properties.
The approach allows prospective prediction of transporter both substrate and/or inhibitor affinity and build quantitative structure-activity relationship (QSAR) to enable early optimization of pharmacokinetics, tissue distribution and drug-drug interaction risk.
