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In a recent prospective paper, we investigated the ability of 64CuCl2-PET/CT as a diagnostic agent to detect prostate cancer (PCa) recurrence in 50 patients with biochemical relapse, after prostatectomy or external beam radiation therapy (EBRT) [4].
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The study's crossover design reduced between-individual variation when comparing the number of recorded contacts across prospective (paper, PDA) methods.
PET-CT was not added as imaging modality to our meta-analysis because only one prospective paper [ 32] was available at the time of the structured search.
When compared to other studies in the literature, this prospective paper shows very low surgical rates, comparable to some already presented in the past [ 9, 17, 31, 34- 36], but substantially different from others [ 18, 37].
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The facilitators and barriers search filter was developed through a series of iterations and remained very broad, to capture as many prospective papers as possible.
Both cross-sectional and prospective papers identified steatosis as a predictor of liver fibrosis [ 51– 53], with a major role related to metabolic rather than virus-induced steatosis, even if data are sometimes discordant.
9 32 More recent prospective papers have stressed the importance of emotional distress, and social factors as risk factors for reduced recovery, 33 post-traumatic stress disorder (PTSD), 15 33 catastrophising, 34 kinesiophobia 28 31 35 and stress-response 36 are factors associated with the risk of persistent complaints.
One prospective memory paper uses a task that requires this unique function of prospective memory whereas another prospective memory paper uses a variant of a venerable vigilance task.
Gross ascertainment differences between prospective diaries (paper and PDA) were assessed using the Bland-Altman test.
A large Cancer Research UK-funded prospective study (paper in press) examined MDT members' communication about clinical trials and the involvement of individual team members in trial recruitment.
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