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During the design of the study we considered a controlled setting with prospective hypothesis testing.
The retrospective assessment approach has not been presented as better than a purely experimental prospective hypothesis testing method but complementary to it.
With this prospective hypothesis, TLR2 was found to be significantly differentially expressed in the interaction between gender and day of infection from pre-infection to 3-days post, and from 3-days post to 6-days post (Table 1).
The primary goal of the microarray assay was to repeat validate the super array results with a prospective hypothesis of gender specific differential expression during the course of infection on a genome-wide level and with independent replicates.
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This prospective, hypothesis-generating Phase II single-arm study gathered dosimetric data and clinical outcomes of APBI delivered with IMRT APBIMRTT).
Given the disproportionate prevalence of pediatric obesity in these populations, large scale, prospective, hypothesis-driven studies using valid, comprehensive instruments [ 66] are needed to explore the interaction of family and household characteristics, on the development of children's eating and physical activity habits and the subsequent effects on weight status.
Based on the previous findings in a phase 2 study, 22 the prospective primary hypothesis was that subcutaneous injections of teduglutide would result in a higher GRS than placebo in patients with SBS dependent on parenteral support.
In this way, we can identify a large number of prospective phone hypotheses that never appear in the word-based phone lattices.
50 consecutive patients operated with total knee arthroplasty at Martina Hansens Hospital between February and September 2003 were included in a prospective observational, hypothesis-generating study.
Here, in a prospective-retrospective hypothesis-driven analysis (Simon et al, 2009), we investigated the role of CXCR3 and CCR5 expression and polymorphisms (i.e., rs2280964 for C XCR3 and Δ32 for CCR5) by sequencing and profiling infused TILs from patients with metastatic melanoma undergoing adoptive therapy (N=142).
Although data collection was prospective, the study hypothesis was formulated later, which makes this essentially a retrospective study.
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CEO of Professional Science Editing for Scientists @ prosciediting.com