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As mentioned above, the prospective gathering of drug use facilitates unbiased risk estimates provided exposure is precisely defined by reference to a well-defined event with a clearly recognizable onset.
The strengths of the current study include its community-based recruitment, its prospective gathering of a large amount of laboratory and clinical information and its almost complete follow-up.
While a prospective gathering of data would have probably influenced our attitude in favour of de-escalation, it would be the clinical trial design of choice to answer the question of de-escalation efficiency.
A strength of the current study is the prospective gathering of data – only a small number of events were recorded retrospectively but, even so, patients were in the ICU when tracheostomy was performed, so the chance of having missed retrospective data was small.
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Novel survey methods should be trialled and prospective data gathering (surveillance) employed wherever feasible.
These methods are different from the process of public health triangulation we describe here that involves trends in large geographical areas and rarely employ prospective data gathering.
Further evidence using prospective methods gathering more detailed information about comorbidity may add to our understanding about the measurement of participation restriction as related to the number and severity of co-existing impairments.
Additional bias is potentially introduced by including baseline data of patients entering the study diagnosed with CFRD prior to prospective data gathering that was initiated in 1992, at which point all patient data was prospectively reviewed in this cohort study.
Dear Rajeev, In one of my recent columns, From an Employer's Wish-List to Your CV, Part 1, I outlined a strategy for writing your CV that involved identifying the needs of your prospective employer and gathering together evidence of your suitability.
Furthermore, we regarded the following extrapolation approaches as dose investigating: a) PK, PK−PD or dose-PD M&S studies, b) prospective literature reviews gathering information on effective medicine use in children and c) use of completed paediatric dose investigation trials when listed in the opinion.
Elizabeth Lucchesi, a real estate agent with McEnearney Associates in Old Town Alexandria, said prospective buyers' information-gathering should extend beyond a project's sales staff.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com