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The high-dose tigecycline regimen that Cunha proposes for multidrug-resistant organisms has never, to our knowledge, been evaluated in randomized trials or even in large prospective evaluations.
As yet, the applicability and significance of PD-L1 expression as a baseline biomarker must be interpreted with caution and further prospective evaluations are needed, including the results of ongoing randomized clinical trials that are prospectively evaluating PD-L1 IHC as a companion diagnostic platform (NCT01721746).
Our results have to be confirmed by further multicenter prospective evaluations.
Prospective evaluations of hysteroscopic procedures report that the endometrium heals fastest with polypectomy and slowest following septoplasty [44].
Prospective evaluations of how effectively such policies are likely to meet sustainability goals have nonetheless remained challenging.
There are few prospective evaluations of the safety and efficacy of NKS, and studies of its early use in difficult cannulation have been inconclusive.
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Design: Prospective evaluation.
A prospective evaluation study is currently in progress.
Design: Prospective evaluation with a convenience sample of 10 subjects.
Prospective evaluation of feasibility, before an evaluation of effectiveness, is now indicated.
Put simply, this approach could be summarized as internal validation, external validation, and continued prospective evaluation.
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