Sentence examples for prospective compounds from inspiring English sources

Tea polyphenols -epigallocatechin-3-gallate (EGCG) and theaflavin-3-3′-digallate (TF3) are two prospective compounds in cancer prevention and treatment.

Virtual screening of the ChemBridge CNS-Set™, a database having compounds with a better suitability for central nervous system based disorders followed by docking and analysis of the ligand protein interactions resulted in the identification of eight prospective compounds with considerable diversity.

The most prospective compounds; the pyrimidinylamino coumarin derivatives 8, 17 (IC50.41111, IC50 0.421 mM) and the chalcones 22b, 22e (IC50.37171, 0.374 mM) that displayed the highest activity can be a base for lead optimization and simple but efficient design of new compounds.

The exploration of 5 6 fused rings as alternative S1 moieties resulted in two compounds which demonstrated improved solubility and reduced food effect compared to the clinical candidate, compound A. Herein, we describe the synthesis and structure activity relationship (SAR), together with the physicochemical properties and pharmacokinetic (PK) profiles of some prospective compounds.

The same prospective compound set used to evaluate the 2D model performance was used as a benchmark for the 3D models.

We contend that coevolution of Nrf2-activating secondary metabolites by fungi and other extant microbiota may provide prospective compound leads for the design of new therapeutics to target activation of the human Keap1 Nrf2 pathway for treating degenerative diseases of ageing.

The safety and toxicity of the prospective compound is then studied, followed by pre-clinical and clinical studies.

A special feature of SARMs that sets them apart from many other activity landscape representations is that they closely link descriptive compound data analysis (a primary task of activity landscape modeling) and prospective compound design.

The conditions characterizing strepsipteran primary larvae (abdominal segment XI and cerci present) and secondary larvae (external wing buds recognizable as external convexities) are apparently the result of reversals, like the early appearance of the prospective compound eyes (see [ 17]).

3D-QSAR is a robust technique in drug design process used to predict the inhibitory activities of the prospective lead compounds by applying the knowledge of three-dimensional properties of the lead compounds through a chemometric approach [ 9, 10].

The three-dimensional protein structures can be used to understand ligand binding and to rationally design novel ligands as prospective drug compounds.