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75 Pepper et al and Vériter et al have summarized the utility of alternative transplant sites in experimental models and their prospective applicability to the clinical setting.
> -wrap-foot> aadditional relevant articles are cited within the articles in this group Following categorization, we considered the prospective applicability of the research strategies for the Hells Canyon reach of the Snake River.
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Once refined, the assay must be applied to a prospective patient population to demonstrate applicability.
However, because of the simplicity of this tool, and these promising results, further prospective study to validate the applicability of the SI is warranted.
The second outcome was the longitudinal predictive value derived from registry linkage and other prospective studies that would support the applicability of the AHPV test in primary screening with at least a three year screening interval.
We demonstrate the real-life applicability of SQUIRREL by a prospective virtual screening study, where a potent PPARα agonist with an EC50 of 44 nM and 100-fold selectivity against PPARγ has been identified.
RR: Relative Risk; OR: Odds Ratio Regardless of statistical significance and degree of mechanistic understanding of genotype-phenotype associations, their clinical applicability should be tested in prospective randomized trials.
However, more prospective studies are needed to affirm the clinical applicability of p16 hypermethylation in larger groups of patients.
Though these results are promising, we realize that further prospective studies are needed to assess a broad clinical applicability of this biomarker for suicidality in different populations, ages, ethnicity, independent of the diagnosis.
While they are promising tools, lack of specificity for fibrosis, fluctuation over time and lack of prospective studies presently limit their value and practical clinical applicability.
Based on their results, Jettinghoff recommended that a prospective study should be carried out to assess the applicability and effectiveness of the PW intervention for sick-listed employees with stress-related mental disorders (SMDs) [ 13].
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