It would be useful to see more studies using the algorithms for treatment as suggested in the WHO guidelines 1 and the Clinical Handbook on Dengue Management, 9 with local adaptations in prospective studies maybe in outbreak situations and use of qualitative methods to assess the usefulness of D/SD in real-life circumstances.
Additionally, we have identified and validated a group of unclassified genes (8%) that could be further investigated of their functional prospective roles in drought adaptation mechanisms.
The adaptations can be prospective (e.g. stopping a trial early due to safety or futility or efficacy at interim analysis); concurrent (e.g. changes in eligibility criteria, hypotheses or study endpoints) or retrospective (e.g. changes to statistical analysis plan prior to locking database or revealing treatment codes to trial investigators or patients).
Most recently an adaptation of the prospective ECG-triggered CT technique to a dual-step mode has been introduced to provide ventricular functional analysis at a low radiation dose [13].
For example, the Food and Drug Administration FDAA) recently produced some guidelines for industry 7 that include an explanation of how adaptive designs must be prospective: "The term prospective here means that the adaptation was planned (and details specified) before data were examined in an unblinded manner by any personnel involved in planning the revision".
To evaluate the effectiveness of a broad, literature-based night shiftwork intervention for enhancement of emergency physicians' (EPs') adaptation to night rotations.A prospective, double-blind, active placebo-controlled study was conducted on 6 attending physicians in a university hospital ED.
An electronic adaptation of the National Institute of Mental Health prospective Life Chart Methodology (NIMH-LCM™) will be used specifically for assessing clinical outcomes during both the retrospective and the prospective phases of the study.
After in vivo implantation, decellularized heart valve scaffolds drive their same repopulation by recipient's cells for a prospective autologous-like tissue reconstruction, remodeling, and adaptation to the somatic growth of the patient.
These adaptations are currently being applied in a prospective study on proactive supportive care in patients with COPD.
It is plausible, for example, that the lowered systolic blood pressure observed in highly sedentary men in our study may reflect adaptations in hemodynamic responses to sitting (22), but confirmation in prospective cohort studies are needed.
It is an adaptation of Iphigenia at Aulis by Euripides, about the prospective sacrifice of Iphigenia by her father Agamemnon.
