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Finally, a limiting factor in the prospection of new molecules with antimicrobial potential is the toxicity exhibited by several compounds.
Our ultimate goal is to provide a platform that allows scientists to perform the prospection of new cross-reactive targets, or even to identify the molecular basis for triggering an adequate immune response, envisaging a new generation of vaccines.
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Likewise, the myriad of ecological niches occupied by microbes provides the opportunity for prospection of novel biochemical pathways, allowing for better conversion of residual biomass.
Efforts to further understand metabolic changes in microorganism during the harsh ethanolic fermentation steps, as well as the prospection of novel routes and strains for biomass conversion, indicate that metabolomics plays an indispensable role in diagnostics and metabolic engineering.
This database can facilitate prospection of novel leads and their analogs for various diseases from the repertoire of natural molecules.
This database can facilitate prospection of novel leads for these disorders from the repertoire of natural molecules.
Phytochemica PDMs have maximum density in the 'Lipinski region of interest' reflecting their drug-like properties and hence, their utility in prospection of novel leads.
Phytochemica repertoire (as demonstrated in Figure 1) can facilitate prospection of novel leads and their analogs through implementation of virtual screening protocol.
SerpentinaDB PDMs have maximum density in the 'Lipinski region of interest' reflecting their drug-like properties and hence their utility in prospection of novel leads.
Hence, compilation of such datasets is essential step towards in-silico drug discovery that hastens the process of prospection of novel leads from natural repertoire with drug-like properties in terms of their biological behavior and toxicity.
Besides the enormous use of PDMs and their derivatives in drug discovery there is still lack of composite repertoire of these natural molecules which can be directly used for prospection of novel leads identification.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com