In this issue of Diabetes Care, Dr. David Sacks has nicely delineated the pros and cons of the measurements of glucose concentrations and A1C levels and the resulting effects on using each to diagnose diabetes (1).
The mechanisms behind the direct effects on skin integrity of elevated TNF-α independent of its pro-inflammatory role are poorly delineated.
We have delineated a novel pro-inflammatory pathway leading to VCAM-1 expression through activation of Rac1 by the Rho-GEF Trio, involving the transcription factor Ets-2, but excluding NF-κB and MAP-kinase pathways.
TH-positive SN cells were counted by stereology blind with regard to the experimental condition using a Leica DM6000B motorized microscope coupled with the Mercator Pro software (ExploraNova, La Rochelle, France).The SN was delineated for each section and probes for stereological counting were applied to the map obtained (sampling and size of probes, see Additional file 4: Table S3).
As IFN-γ possesses pro- as well as anti-inflammatory properties, we delineated its role in the pathogenesis of TSS.
In a small number of instances, the role of individual pro-inflammatory genes and mediators linking inflammation and intestinal tumorigenesis has been delineated (5).
Perhaps the most important aspect of these studies is that use of anti-angiogenic agents as radiosensitizers in vivo was delineated based on the biology of radiation-induced generation of the pro-apoptotic second messenger ceramide in cultured endothelial cells.
This ontologic infrastructure delineated a cardiac neighborhood encompassing up-regulated progenitor-specific genes with a pro-cardiac phenotype, cardiovascular transcription factors, and interconnecting hubs (SDF-1/CXCR4, VEGF/Flk-1, BMP2/BMP2r) that are relays to major canonical signaling highways.
He is a pro-life, climate change-denying conservative who wants to roll back all functions of the federal government not specifically delineated by the U.S. Constitution, including Obamacare and Social Security.
It delineated my credits.
Stations were assigned, tasks delineated.
