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SBD was the name given to a motif originally recognized by Fantini et al [1] in a number of glycolipid-associated proteins, and was proposed to interact with sphingolipids in membrane microdomains.
As I mentioned during my earlier review, the K that is proposed to interact with rRNA in Giardia does not align with the conserved R but is instead two residues away on the loop.
SdiA has been proposed to interact with indole [ 73], in addition to acyl homoserine lactones (AHLs) from other bacteria.
and AcCYS (43 135 a.a).. Three conservative regions, proposed to interact with cysteine protease, were found in SiCYS-N, Orzyacystatin I, CeCPI, and AcCYS: a G residue near the N-terminus, a central QXVXG motif in the first hairpin loop, and a W residue in the second hairpin loop near the C-terminus putatively forming a tripartite wedge.
Several amino acid residues have been proposed to interact with OT and OT-GKR in the OTR model where the red bars represent docking with OT-GKR, and the black bars indicate docking with OT molecule (Fig. 2D).
Esrrb is also proposed to interact with Nanog and thereby play a reciprocal role in regulation of Oct4 expression (Zhang et al., 2008).
It is also striking that genetic screens have never identified fidelity mutations in domain 3, which is also proposed to interact with aa-tRNA.
Due to structural mimicry SifA has further been proposed to interact with G-proteins.
Another protein that has been proposed to interact with PilQ is PilC.
In this way, the local sequence interacts with the active site of the deacetylase enzyme and the distal sequence is proposed to interact with a different region of the enzyme.
Similar observations have been made for S100A6 which has also been proposed to interact with AnxA2.
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