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During DNA translocation, the nuclease domain was proposed to interact with DNA through electrostatic interactions at a second DNA-binding site located at a surface opposite to the nuclease active site.
CcmF has a WWD motif (see Figure 1) that is proposed to interact with heme, via hydrophobic interactions, on the periplasmic side of the membrane (this heme molecule is transferred from CcmE to the cytochrome).
These positively selected residues have only one residue that overlaps with those proposed to interact with NKG2D, thus suggesting the interaction with molecules other than NKG2D.
Due to structural mimicry SifA has further been proposed to interact with G-proteins.
The cytosolic domain of Sec61β has been proposed to interact with ribosomes or exocyst complexes (Levy et al., 2001; Lipschutz et al., 2003; Toikkanen et al., 2003).
Neurofilaments (NFs) have been proposed to interact with one another through mutual steric exclusion of their unstructured C-terminal "sidearm" domains, producing order in axonal NF distributions and conferring mechanical strength to the axon.
Another protein that has been proposed to interact with PilQ is PilC.
Since T-548 lacks the domain proposed to interact with α7-nAChR, this truncated AChE molecule predictably does not exhibit an ability to bind to the receptor.
It is also striking that genetic screens have never identified fidelity mutations in domain 3, which is also proposed to interact with aa-tRNA.
Members of the PLP family were proposed to interact with the actin cystoskeleton after their association with actin-enriched membranes [12].
BTG has also been proposed to interact with and modulate the function of differentiation regulators such as Hoxb9 [5] and BMPx [6].
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