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CD98 has also been proposed to be functionally linked to CD147 [41].
Position EL2.52 forms extensive contacts with the co-crystallized ligand in the β2-AR and the A2A receptor [5], [12], and has been proposed to be functionally important also for other GPCRs on the basis of molecular modeling.
One motif in the cytoplasmic domain of APP that has been proposed to be functionally important is 667-VTPEER-672 which forms a type I β-turn and amino-terminal helix capping box structure and contributes to the stability of a carboxyl-terminal helix structure [29], [30].
This residue has been proposed to be functionally important in HS binding (24) and has undergone a missense mutation in a human UFS family (10).
As a high sub-plasma membrane Ca2+ concentration is proposed to be functionally important in both exocytsosis [21] and membrane unwrinkling during phagocytosis [10] and cell "spreading" [11] of neutrophils, we have in the simulations used parameters which are applicable to micro-anatomy and Ca2+ in these cells.
Similar(53)
Recently studies have shown that Mincle can form a receptor complex with CLECSF8 (CLEC4D or MCL) and FcεRIγ, and this heterotrimeric complex is proposed to be the functionally optimal form for these CLRs (Lobato-Pascual et al., 2013).
We were intrigued by the ability of 2μ ULS1 to suppress mot1-301 becalthoughhoULS1ULS1 has been functionally linked with the SUMO pathway, it is proposed to be another STUbL that functionally overlaps with Slx5-Slx8.
Functionally, CBR2 is proposed to be involved in the metabolism of endogenous or inhaled carbonyl compounds (Ebert et al., 2015) and, interestingly, has also been described to be involved in cellular differentiation, such as adipocyte differentiation (Wenz et al., 1992).
Functionally, PPP1R9B is one of the regulatory subunits of phosphatase-1a and is proposed to be a new tumour suppressor [ 69].
A full-length Merlin mutant (A585W-Merlin, in which Ala585 is substituted with Trp) has been shown to be functionally dormant and proposed as fully closed in its conformation, and this mutant shows no detectable binding to EBP50-CT.
They have to be functionally equivalent campuses.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com