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The proposed rationale for using a combination of two or more different antimicrobials is several fold.
The results for our initial design for the mechanism of drug combination synergy (Figure 1e) confirmed the proposed rationale: Gemcitabine serves as a drug establishing a baseline perturbation on the inter-module network, but Bortezomib could add a more focused perturbation on key gatekeeper modules which are linked to the checkpoint perturbation established by Gemcitabine (Figure 5d).
The proposed rationale for this finding was that before surgery a large network of neurons was activated for each visual stimulus.
Authors' response: We think that the proposed rationale holds only in species in which nurse cells have the same origin as germ cells, like for example in Drosophila.
However, the proposed rationale is purely heuristic and cannot be independently verified as no technical vehicle is currently available for this purpose".
The proposed rationale is that an initial high Hbmass will not allow Hbmass to increase substantially following altitude training, whereas an initial low value will likely lead to meaningful enhancements in Hbmass.
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Any or all of these proposed rationales might be challenged either on the ground that the rationale itself is normatively objectionable or that the means used to advance it are unfair or unduly restrictive of liberty or the like.
Many acupuncture trials fail to offer a meaningful rationale, but proposing a rationale can help investigators to develop and test a causal hypothesis, choose an appropriate control and rule out placebo effects.
We have proposed a rationale whereby the mechanical stiffness of the knee may influence sensations of joint stability.
By combining these experimental data with modeling studies, we have proposed a rationale that explains the impacts of the most useful mutations.
The purpose of this study was to determine to what extent contemporary acupuncture clinical trials proposed physiologic rationales and present the findings in the context of other characteristics of the studies.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com