In 1994, Sjogren proposed a progression of SSc with gastrointestinal involvement, vascular damage, neurogenic impairment, and myogenic dysfunction with the replacement of normal smooth muscle by collagens fibrosis and atrophy [7].
It is worth emphasizing that our proposed version progression modeling can work as a plug-in component to be embedded into most of the existing latent factor-based algorithms.
Such a limitation would be consistent with the proposed slower progression through S-phase in CAF-1 mutants [ 40, 54].
If the first-line efficacy of the platinum-based chemotherapy was good, a combination of cisplatin and cetuximab could be proposed after progression.
Based on these findings, a clonal evolution has been proposed with progression disease achieved through branching, nonlinear pathways, which is a typical pattern of a complex ecosystem of clones competing for evolution [ 17, 33– 33].
The prognostic accuracy of biomarkers is substantially attenuated in older age; the proposed stepwise progression from biomarker change to dementia is not always apparent and time course is highly variable and there is not always a clear biological gradient between biomarker burden [ 41, 43].
This has been best developed for the Society Island radiation where a number of workers have proposed a "progression rule" model of evolution – lineages sequentially colonize newer islands within an archipelago as they are formed [ 4] - for the well-studied Partula species of Moorea and Tahiti [ 43, 46, 49- 53].
Thus, Vhl and Trp53 double deletion does not automatically cause proliferative dysregulation of kidney epithelial cells in vivo but eventually leads to the evolution of lesions that appear to follow a pathway of simple cyst to atypical cyst to neoplasm that is similar to the proposed disease progression model in kidneys of patients with an inherited VHL mutation.
There is controversy regarding whether these papillary tumours progress to invasive disease; some studies propose that progression occurs in a maximum of 10 20% of cases (Knowles, 2001).
In this paper, we propose a progression semantics for first-order normal logic programs, and show that it is equivalent to the well-known stable model (answer set) semantics.
