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In the present study, a high FF/VI strength (800/100 μg) was selected, which represented a fourfold multiple of the proposed highest therapeutic strength (200/25 μg) and produced systemic VI exposure that is likely to be considerably above that seen in subjects with asthma or COPD, particularly as VI exposure (Cmax) is lower in these patient groups than in healthy subjects [36].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com