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Sulfur has also been proposed as a sample-inherent internal standard [ 77]; however, it is not evenly distributed in most tissues and, because of its high first ionization energy, similar problems as mentioned for carbon may be expected.
Recently, it has been proposed as a valuable system for sample preparation in matrix-assisted laser desorption/ionization mass spectrometry and as sample introduction system for electrospray mass spectrometry.
MC is proposed as a way to estimate nonlinear sample distances by MST without any need for tuning parameters.
Sputum cytology analysis (SCA), in which smears are examined and graded according to an algorithm, has been proposed as a means to ensure sufficient sample quality.
This study was part of the Helios2 project mainly aimed at investigating the relationships between risk of skin tumours and amount and type of skin melanin (measured by its metabolites with HPLC method from hair sample), proposed as a more precise indicator of skin susceptibility (Zanetti et al, 2001).
Multivariate adaptive regression spline (MARS) together with Monte-Carlo (MC) sampling was proposed as a reliable descriptor subset selection strategy.
Broader taxon sampling was proposed as a practical avenue for accurate phylogenetic estimates (Zwickl and Hillis 2002; Dunn et al. 2008; Parfrey et al. 2010; Leigh et al. 2011).
Trace sampling is often proposed as a practical solution for this problem.
Previously the anti- O. ostertagi antibody level in individual milk samples has been proposed as a useful indicator of which animals would benefit most from treatment [ 3, 11, 12, 16].
The HPV status of cytological samples has been proposed as a marker to identify patients with underlying high-grade cervical intraepithelial neoplasia (CIN) [ 31] and current clinically approved HPV tests detect the bulk of high-grade CIN and invasive cervical carcinoma.
Nitric oxide signaling pathways have been implicated in the regulation of airway hyperresponsiveness and recently of fractional exhaled nitric oxide (FeNO) (Van Amsterdam et al. 2000) and the pH of exhaled breath condensate (EBC) samples has been proposed as a noninvasive biomarker to assess airway inflammation (Rosias et al. 2004).
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