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Benchoua et al. proposed activation of different and specific pathways in the core or in the penumbra area of the brain infarction.
Applying this method to lithium chloride we observed anterior truncations in medaka embryos in agreement with its proposed activation of Wnt signalling.
The proposed activation of the gene expression of hapX by the transcriptional regulator SrbA constitutes a so far unknown way of regulating iron homeostasis based on the amount of metabolically available iron.
In mammalian cells, the use of long dsRNA has been restricted due to the proposed activation of an antiviral defense system that blocks protein translation leading to cell death [ 3].
In recent, 3 subtypes of imidazoline receptors have been proposed; activation of I-1 receptors regulates the blood pressure through central nervous system [ 4], whereas I-3 receptors participate in insulin release [ 5] and activation of I-2 receptors (I-2R) increases glucose uptake into muscle cells [ 6, 7].
After the characterization of agmatine as the endogenous ligand of this receptor, 3 subtypes of imidazoline receptors have been proposed; activation of I-1 receptors regulates blood pressure [ 11], whereas I-3 receptors participate in insulin release [ 12] and activation of I-2 receptors (I-2R) increases glucose uptake into muscle cells [ 13, 14].
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The prevailing hypotheses propose activation of apoptosis via death receptor upregulation and/or inhibition of NF κB-mediated pro-survival signaling.
Thus we propose activation of the bone anabolic effects of PTH especially in the first period after fracture, when most important stabilization processes occur.
Accordingly, a model proposing activation of PKC by ER-associated 1,2-DGs needs to include PKC localization to the ER or contact sites between the plasma membrane and the ER membrane.
Furthermore, evidence from primary visual cortex indicates that increased gamma oscillations are associated with reduced firing rates of principal excitatory neurons, the authors proposing activation of a neuron's suppressive surround as a mechanism for these phenomena (Gieselmann and Thiele, 2008).
This could argue in favour of proposed activation mechanisms that are based on modifications of residues by nitrosylation in the catalytic region rather than extensive conformational changes [32].
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