We propose to bound by, where is the code rate (the exact code rate is dependent on the optimization result, and may be slightly different from the target code rate).
For correcting this problem we propose to bound Wi within two limits (+b and −b).
In addition, the RsTSPO form containing a W38C mutation located in the middle of loop 1 where both PpIX and PK11195 are proposed to bind decreased the binding affinity of PK11195 by 3-fold.
In contrast to LY315920, a small molecule that binds directly to the sPLA2 active site for inhibition [ 33], a 2000 Dalton PIP-18 peptide is proposed to bind to the hydrophobic binding pocket near the N-terminal helix of sPLA2 [ 11].
These oxidized structures are proposed to bind NADP+ because of this cofactor binding in a conformation that would not (and does not) provide reduction of FAD (detailed below).
Binding affinities measured experimentally for various mutants clearly verified the predictions made on the basis of the simulations; while mutation of the residues proposed to bind the phosphate moiety disrupts the binding of both Pi and G3P, mutation of glycerol-interacting residues disrupts only G3P binding, with no effect on Pi binding.
The molecular motor myosin is proposed to bind to actin and swing its light-chain binding region through a large angle to produce an ∼10 nm step in motion coupled to changes in the nucleotide state at the active site.
89Zr-labeled trastuzumab has been proposed to bind the shed extracellular domain of HER255, which contains the binding site for trastuzumab.
The TR family DDT is not well characterized, it contains the DDT (DNA-binding homeobox and different TFs) domain that has been proposed to bind to DNA (Doerks et al. 2001).
In fact, PU.1 has been proposed to bind RNA [ 59] and to perform an antagonistic function to the RNA binding proteins TLS and NONO in the regulation of splicing [ 59, 60].
The commission proposes to bind current major international efforts and use all their financial resources in the post-2015 perind in "a new, innovative way".
