We propose that these alterations triggered by prenatal activation of microglia provide a cellular basis for the neuropsychiatric defects induced by prenatal inflammation.
We propose that these alterations primarily represent an adaptive response.
We have found a variety of gene alterations at the breakpoints of D. mojavensis chromosome inversions and propose that these alterations contributed to their adaptive value.
We propose that these alterations in autophagosome clearance can originate from a decreased efficiency in the mobilization of autophagosomes from their site of formation toward lysosomal compartments along the microtubule network, thereby impeding the assumed neuroprotective functions of autophagy.
For each theme proposed, the alterations occurred immediately after surgery, time after surgery and finally time compared to today, at the time of the interview, are investigated.
We propose that through these alterations, cortical networks are better able to efficiently encode information.
Based on these findings, we propose that alterations in the serotonergic system at an early stage may contribute to abnormal behavioral phenotypes in adult patDp/+ mice.
Although many models have been proposed to detect these alterations, it is not clear which model is appropriate before visual inspection the signal, noise and models for a particular profile.
We propose that alterations in the miRNA MRE interaction caused by these MRE-SNPs could be an alternate mechanism underlying aberrant gene expression, which may contribute to predisposition, pathogenesis, inter-individual variation in gene expression, and heterogeneity of ASD.
Committee members received Mr. Annan's plan in March with the expectation that they would review it but not propose major alterations before sending it along to the overall assembly.
Because of the involvement of the actin network in such diverse interactions, we propose that alterations in the actin cytoskeletal function may be an important aspect of generalized decrease in cellular functions associated with aging.
