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We performed this simulation experiment varying the proportion verified (v = 10, 30, and 60%).
The highest proportion verified histologically was for rectal cancer (81.4%%), while breast cancer was the cancer type most likely to be verified cytologically (36.8 %).
Our intent in varying the proportion verified was to vary the frequency of the cell counts while keeping the relationship between the diagnostic test and outcome the same.
The highest proportion verified by one of these two methods was in the age group 20 – 29, and the proportion was lower the older the age group.
The annual proportion of diagnoses that were verified histologically was around 60percentt, while the proportion verified cytologically increased from 15 to around 20percentt in the studied period.
As expected, both variability and coverage improved with a higher proportion verified: with 60% of participants verified, the 2.5th – 95th percentiles of the AUC were 0.713 – 0.786 and coverage was 93%.
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Data validity and completeness were evaluated using indices such as the proportion of microscopically verified cases (MV%), the proportion of death-certificate-only registrations (DCO%), and the mortality to incidence ratio (M: I) [ 35].
Tumours classified as 'others', including 'not histologically verified', represented the largest proportion of tumours verified by MRI, whereas pilocytic astrocytoma and primitive neuroectodermal tumours represented the smallest proportions.
In Denmark, the proportion of morphologically verified tumours reaches 89%.
Our study also illustrates that the proportion of laboratory verified HUS cases might be low.
Third, the high proportion of microbiologically verified TB cases minimized risk of misclassification.
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