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A receiver operating characteristic curve was obtained by plotting the true-positive proportion (sensitivity) against the false-negative proportion (1 – specificity).
We calculated that we would need a sample size of 139 for an expected proportion (sensitivity and specificity) of 0.90 to have a 95% confidence interval with a total width of 0.10.
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Confidence intervals for proportions (sensitivity and specificity) were calculated using the Wilson score method [ 9].
We used McNemar's test to determine the statistical significance of differences in paired binomial proportions: sensitivity and specificity.
Pooled proportions (sensitivity and specificity) were calculated through the weighted averages taking into account the sample size of each study.
However, the simple diagnostic test methods are based on weighted proportions (sensitivity, specificity), relative risks (likelihood ratios), odds ratios and regression (SROC, meta-regression).
†P value for test of difference of proportions, sensitivity of cytology in control arm at 3 years versus HPV testing in intervention arm at 3 (P=0.1934), 5 (P=0.4871), 8 (P=0.0255), and 10 years (P=0.0010).
†P value for test of difference of proportions, sensitivity of cytology in control arm at three years versus HPV testing in the intervention arm at 3 (P=0.0481), 5 (P=0.8970), 8 (p=0.0294), and 10 years (P=0.0012).
Studies were analyzed separately for homogeneity of results by clinical sign and by haemoglobin threshold through chi-square test for proportions (sensitivity and specificity), through Cochran Q for LR's and DOR's [ 15] and through DOR graphic plotting of individual studies, along with their 95% CI graphs [ 16].
When the implication index is at least 1 (meaning the functional two-SNP model is supported in our domain knowledge), as this proportion increases, sensitivity fluctuates around the baseline sensitivity (37%) at random initialization when BP is not used.
Bill Shankly's hoary quote about the game and life and death has taken its usual place in the commentary on these events but the sense of proportion and sensitivity from all quarters should be applauded.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com