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A proliferation of recent genetic investigations and reviews suggest that multiple rare allelic and/or structural variants and therefore an architecture characterized by substantial locus and allelic heterogeneity may explain a substantial proportion of susceptibility to major neuropsychiatric disorders [3], [4], [79], [82], [83], [84], [85].
Genetic variation explains a significant proportion of susceptibility to common disease [ 1- 5].
Our study revealed that ACPA-negative RA shares a large proportion of susceptibility loci with ACPA-positive RA for non-HLA alleles.
For example, all of the currently known rheumatoid arthritis (RA) risk alleles, including the major histocompatibility complex (MHC) locus, have been estimated to explain less than half of the total genetic component (Raychaudhuri et al. 2008), indicating that a substantial proportion of susceptibility variants remain undiscovered.
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Ninety-five perconfidencedence intervals (CIs) for proportions of susceptibility were calculated by using the binomial method.
A summary of the relative proportions of susceptibility and resistance profiles from all uropathogens against each antibiotic is presented in Table 3 along with their confidence intervals set at 95% level of significance.
* Propotion of susceptible (S), intermediate susceptibility (I) and resistant (R) isolates * Proportion of susceptible (S), intermediate susceptibility (I) and resistant (R) isolates The results of the present study were based on an analysis of milk samples submitted to an Estonian National Veterinary Laboratory over a three-year period.
While a large proportion of cancer susceptibility is heritable, the underlying genetic components are largely unknown.
17 Shared lifestyle among family members seems to explain only a small proportion of familial susceptibility to cancer.
Importantly, a significant proportion of inherited susceptibility to common disease may be attributable to the effects of multiple, low frequency variants with moderate effects in a number of genes (Bodmer and Bonilla 2008).
While the genetic causes of cancer have been intensively studied, it is becoming evident that a large proportion of cancer susceptibility cannot be attributed to variation in protein-coding sequences.
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CEO of Professional Science Editing for Scientists @ prosciediting.com