To assess usefulness, it is important to include in addition the base rate (proportion of submissions that are fundamentally suitable for publication) and the selection rate (the proportion of submissions accepted).
The reason for the high rate of restriction remains unclear, though CADTH also restricts a high proportion of submissions overall.
NICE accepted the highest proportion of submissions with ICERs higher than the threshold out of all the HTA agencies.
In recent years, there has been a slight decrease in submissions, but the proportion of submissions diagnosed with PRRS has increased from 2%to10%0% [ 31].
NICE recommended the highest proportion of submissions overall, with an acceptance rate of 76% (87/114); 66 of these were accepted unconditionally and 21 with restrictions.
Nevertheless, a considerable proportion of submissions were accepted with ICERs higher than the threshold, especially in the case of NICE (Table 1).
PBAC recommended the lowest proportion of submissions (42% [79/187]), 73 of which were accepted without restrictions and 6 with restrictions (Table 1).
Perhaps because of the die-off of dogs of that age from all causes and the relative ease of carrying a puppy to the laboratory, the proportion of submissions (68% of all samples) from dogs <1 year was high, even relative to the population (37% of all dogs).
NICE recommended the highest proportion of submissions with ICERs higher than the threshold (34% accepted without restrictions; 20% with restrictions), followed by PBAC (16% accepted without restrictions; 4% with restrictions), SMC (11% accepted without restrictions; 14% accepted with restrictions), and CADTH (0% accepted without restrictions; 26% with restrictions).
Departments will now have to submit case studies using a standard template that will inform an "impact sub-profile" for each submission, which will rate the proportion of the submission at each level (1* to 4* and Unclassified – 4 is the highest).
