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The data sets containing drugs approved by the FDA to treat cancer, Clinical and Epigenetic focused had the largest proportion of chemotypes relative to the number of molecules (N/M) and the largest proportion of singletons relative to the number of molecules (Nsing/M), greater than 0.84 and 0.78, respectively.
Surprisingly, GRAS, NATx, MEGx, the largest data sets (with more than 2000 compounds), had the lowest scaffold diversity as measured by the small proportion of singletons relative to the total number of scaffolds (Nsing/N lower than 0.69) and relative to the total number of molecules (Nsing/M lower than 0.26).
Interestingly, the library with approved drugs to treat cancer, which has the lowest number of compounds (78, see Table 1), is the most diverse considering the proportion of singletons relative to the number of molecules (Nsing/M = 0.855) and the number of chemotypes relative to the number of compounds (N/M = 0.921).
Depressed values of Tajima's D and Rozas' R2, coupled with an elevated proportion of singletons, is suggestive of population growth.
The D* of Fu and Li [40] reflects the proportion of singletons (mutations carried by a single individual in the sample) compared to intermediate frequency ones.
In comparison, non-African populations exhibit a positive mean value of Tajima's D (0.302) [19], a higher mean value of Rozas' R2 (0.142), and a lower mean proportion of singletons (19%) (data not shown).
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Fifth, the genetic diversity, calculated as the proportion of singleton genotypes, is rather high due to dominating reproduction via seeds.
Late-preterm infants (34 weeks 0/7 days-36 weeks 6/7 days' gestation) represent the largest proportion of singleton preterm births.
All four groups show depressed values of Tajima's D and Rozas' R2 coupled with a high proportion of singleton mutations (Table 1).
Secondly, a higher proportion of singleton haplotypes is observed in susceptible (50%) than resistant 35% despite the bigger sample size for resistant mosquitoes.
The proportion of singleton CNV calls made was significantly different among the 3 platforms (p = < 0.001).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com