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Recently, Jais and coauthors reported that in a multinational study, the proportion of serous cystadenocarcinoma was less than 0.1% and lower than commonly described in the literature (1-3%) [13].
The subtype distribution was representative of the US population, with a larger proportion of serous (42%) and endometrioid (26%) carcinoma (Table 1).
Different histological subtypes may show different genetic association, e.g, the proportion of serous tumours is higher in BRCA1 associated ovarian cancer.
Moore's study had a higher proportion of serous EOC (64.3 vs 52.2%) and more of the endometrioid type (12.4% vs only 4.3% in Van Gorp's study).
Filipinos from the Philippines have the highest proportions of endometrioid (22%) and mucinous (24%) types with the smallest proportion of serous cancers (20%).
Remarkably, we observed a high proportion of serous borderline ovarian tumours (63%), which was also seen in one case control study (Ness et al., 2002).
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Serous tumors on the other hand are thought to arise form surface epithelium and usually present in more advanced stage, which explains the rather high proportion of metastasizing serous tumors in this subcluster.
However, the proportion of non-serous cases was higher in the Ontario case than in the other two sites.
In this series of ovarian tumours, LOH on 17p correlates closely with the aberrant expression of the p53 protein in a high proportion of advanced stage serous adenocarcinomas.
To identify systemic factors associated with the development of central serous chorioretinopathy (CSCR).
Nevertheless, the presence of survival bias within the FOTS data may have skewed the clinical characteristics within the overall data set as suggested by the higher proportions of non-serous cases observed.
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CEO of Professional Science Editing for Scientists @ prosciediting.com