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The minimum P-value was recorded for each of 10,000 replicates and the adjusted P-values were estimated as the proportion of replication P-values less than the corresponding unadjusted P-value.
In bacteria, some exogenous and endogenous sources of DNA damage can inactivate a large proportion of replication forks [ 4, 5].
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The 95% coverage indicates the proportion of replications for which the 95% confidence interval contains the population value of the linear position effect.
The latter is the proportion of replications for which the 95%% confidence interval contains the population parameter value (Muthén and Muthén 1998 2012).
Hit rate is the proportion of replications for which the items with position effects were correctly flagged for exhibiting a linear position effect at the (alpha =.05) level.
Type I error rate is the average proportion of replications for which the items with no position effects were falsely flagged for exhibiting a linear position effect at the (alpha =.05) level.
Many experimental SHIV stocks contain a large proportion of replication-defective, non-infectious, or severely attenuated virions; these may induce immune responses by this mechanism.
The proportion of replications with > 1 false negative increased as the percentage verified increased.
The proportion of replications below the €100,000 per QALY threshold was also calculated.
We evaluated the models using coverage probabilities (the proportion of replications in which the 95%% credible interval contained the true value) and power (the proportion of replications in which a difference in S and C between the two tests of interest was detected).
The type I error rate was calculated as the proportion of replications which gave a statistically significant result (P < 0.05), when the true odds ratio for treatment was 1. Power was calculated as the proportion of replications which gave a statistically significant result, when the true odds ratio for treatment was not 1.
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