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The hazard ratio shows the proportion of relapse rates of predicted-relapse and predicted-RFS patients).
The proportion of relapse was higher within 6 9 months (6%) and 12 15 months (11%) after cessation.
The proportion of relapse was 29.7% (19 of 64) and of sustained response was 70.3% (45 of 64).
It would be useful to assess the proportion of relapse diagnosed mammographically each year in a large cohort to confirm the impressions of this analysis.
Study endpoints included lung CFU counts, time to culture-negative status, and proportion of relapse (culture-positive lungs 3 months after ending treatment).
Another key conclusion from these studies was the need for more effective postremission therapy, as a high proportion of relapse (61.7%, n=21/34) occurred before HSCT.
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An increasing proportion of relapses were observed at the higher end of PC1.
Figure 1 shows the cumulative proportion of relapse-free survival for each quartile of peritumoural CD3+ cell density.
Time to the first relapse was significantly delayed and the proportion of relapse-free patients was significantly higher in the FTY720 groups.
Secondary clinical endpoints analyzed at six months included annualized relapse rate, the total number of relapses, relative reduction in relapse rate versus placebo, and the proportion of relapse-free patients.
At 2 years, no significant differences in clinical outcomes (risk of relapse, ARR, proportion of relapse-free patients, and time to confirmed disability progression) or most MRI measures (including mean change in T1-hypointense lesion volume, and mean change in brain volume from baseline) were observed between any two treatment groups [ 43].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com