In addition, we showed that the DM signature outperforms 4 additional signatures that contain different proportions of proliferation-related genes, the Hypoxia [9] the Wound [5], [6], the IGS [14] and 70-gene signature, which is currently used in clinical practice [3].
Finally, based on the likely division time of hemocytes (20 minutes; [ 36]) and our measured mitotic indices, proliferation of circulating hemocytes in infected mosquitoes explains a substantial proportion of the proliferation seen in our systemic measures.
Furthermore, Figure 4 showed the proliferation rate of active cells and the proportion of proliferated cells per day.
Similarly in the jejunum, the proportion of cell proliferation, enteroendocrine and goblet cells were unchanged between the CON and OB groups, and the IELs proportion was reduced in the OB group (16%, p < 0.0001).
Thus, in contrast to the above similarities between the data sets, the proportion of the proliferation-associated variance that is explained by ER-α differs substantially (figure 3B).
The proportion of the proliferation-associated variance explained by adjusting for ER-α was calculated using the equation: where Var EP) is the percent change in variance after sequentially adjusting a data set for ER-α and proliferation and Var(E) and Var(P) are the percent changes in variance after individually adjusting for either the ER-α or proliferation genes, respectively.
KPC and FKPC tumors showed identical proportions of cell proliferation and death.
It has also been reported that the glial cells in the olfactory bulb and mucosa are very similar in terms of proportions, morphology, rate of proliferation and expression of markers that change over time (Jani and Raisman, 2004; Richter et al., 2008).
This tissue was labelled by cumulative infusion, volumetrically quantified across time, and temporally analysed for the proportion of cells undergoing proliferation.
A significant proportion of SC resumed proliferation at PND30, which suggests a defect in the cell cycle exit and terminal maturation of SC.
