Two recent trials have demonstrated that fluids can improve microvascular perfusion, increasing the proportion of perfused capillaries and decreasing perfusion heterogeneity [27, 28].
Two recent trials have demonstrated that fluids can improve microvascular perfusion, increasing the proportion of perfused capillaries and decreasing perfusion heterogeneity [ 27, 28].
Subsequent image analysis was performed using microvascular density (total or perfused vessel density) and microvascular perfusion (proportion of perfused vessels and microcirculatory flow index) parameters in line with international consensus [22].
TVD total vessel density; PVD perfused vessel density; PPV proportion of perfused vessel; HI Heterogeneity Index MFI Microvascular Flow Indexx.
Paired t test or paired Wilcoxon test MFI microcirculatory flow index, TVD total vascular density, DBS De Backer score, PVD perfused vascular density, PPV proportion of perfused vessels, HI heterogeneity index.
97.9 ± 3.7 0.372 All values are presented as mean ± standard deviation TVD total vessel density, PVD perfused vessel density, PPV proportion of perfused vessels §Significant difference between baseline and shock.
B Small vessel Microvascular Flow Index (MFIsmall--marker of flow) correlates positively with proportion of perfused small vessels (PPVsmall--marker of perfusion) in the subgroup sample (not statistically significant; r = 0.435, p = 0.182).
We calculated perfused small vessel density (PVD), proportion of perfused small vessels (PPV) and heterogeneity of PPV (PPV-HI).
Images were analyzed by semiquantitative scores of flow (mean flow index; proportion of perfused vessels) and density (total vascular density; perfused vascular density) of small vessels (<20 μm).
LPS severely diminished sublingual microvascular flow index (MFI), perfused vascular density (PVD), and the proportion of perfused vessels (PPV), while increased the heterogeneity flow index (HFI) (p < .05).05
LPS, E. coli lipopolysaccharide; ERP, early resuscitation protocol; MVD, microvascular density; PVD, perfused vascular density; MFI, microvascular flow index; HFI, heterogeneity flow index; PPV, proportion of perfused vessels.
