Sentence examples for proportion of mutated from inspiring English sources

This method is even sensitive than mutation detection by sequencing of ABL ATP-binding domain (30) because DNA sequencing can only useful for point mutation detection when proportion of mutated cells is more than 30% (21).

Because both random mutation and positive selection increase the expected proportion of mutated virions with every viral generation, the longer a host is infected, the greater the proportion of a particular mutant (Fig. 4) (15).

By chance, in a very small proportion of mutated cells the combination of genes affected will be such that it endows them with survival advantage and preferential retention during prolonged passaging.

Since the proportion of resistant target sites was relatively low, cells were repeatedly exposed to IDLV-Y2 I-AniI to determine if the proportion of mutated sequences could be increased.

Assuming that CpG o/e ratio was 1 before DNA methylation and increased GC content at the CpG flanking positions could be neglected, we estimated the proportion of mutated CpG sites using the mean o/e ratios of the sea squirt orthologous genes.

Although each of these factors might influence the proportion of mutated SDHB mRNAs in a given sample, the present results indicate that the R46X mRNA mutation occurs in every tested PBMC sample at significantly higher levels compared to the control lymphoblastoid cell lines or wild-type plasmid templates.

By contrast, many pathogenic mtDNA mutations are heteroplasmic, with affected individuals harbouring varying proportions of mutated and wild-type mtDNA [24].

Antigen selection, as determined by significant accumulation of R mutations in the complementary determining region (CDR) regions and/or significant preservation of framework (FR) amino acid sequences, was observed in similar proportions of mutated VH sequences both in the CX3CR1+ and CX3CR1− GC B cell subsets (8/35 and 4/19 clones respectively) (Supplemental Table 1).

The amplicons were hybridized in various proportions of mutated DNA (0, 10, 25, 50, 75, 90 and 100%) on all microarrays.

Such a variation in the phenotypic appearance is presumed to be a consequence of the variable proportions of mutated and normal mtDNA between patients, but also between different tissues within a single individual.

To test whether the serine side chain determines the single-channel conductance, we generated heteropentamers of GLIC wt and S6′G mutant (S/G6′-heteropentamers) by co-injecting oocytes or co-transfecting BHK cells with mixtures of DNAs coding for wt and S6′G subunits, defined by the proportion (a) of mutated DNA versus total DNA.