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Exact(31)
Variation in the number of virions produced by each infected cell does not affect the deterministic calculations of the proportion of mutants.
If the proportion of mutants in the seeding population is 10−4 however, the increase in proportion of respiratory droplet transmissible A/H5N1 virions in the mammalian host is small (fig. S11).
Ottenby sequences had a higher proportion of mutants than NCBI sequences.
The test showed (Figure 1A) that the proportion of mutants was different between those two data sets (p<0.05).
The null hypothesis was that the proportion of mutants was the same in both sources of sequences (NCBI vs. Ottenby).
The largest proportion of mutants (12/33) was positive with respect to both virus multiplication and translation (S/++).
Similar(29)
The proportion of mutant mitochondria determines both disease expression (whether it will affect offspring) and disease severity.
Whether or not the disease subsequently develops seems to depend on whether or not the proportion of mutant mitochondrial DNA rises above a particular threshold.
The baseline estimated proportion of mutant genome was 39%.
The minimum proportion of mutant virus required to make transmission likely is not known, but increased proportion translates into increased probability of transmission; thus, we focused on proportion of mutant virus in the total virus population.
Relatively subtle changes in the proportion of mutant mtDNA can lead to dramatic effects on a patient's phenotype; however, the mtDNA mutation doesn't do it alone.
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CEO of Professional Science Editing for Scientists @ prosciediting.com