Sentence examples for proportion of mutant from inspiring English sources

The proportion of mutant mitochondria determines both disease expression (whether it will affect offspring) and disease severity.

Whether or not the disease subsequently develops seems to depend on whether or not the proportion of mutant mitochondrial DNA rises above a particular threshold.

The baseline estimated proportion of mutant genome was 39%.

The minimum proportion of mutant virus required to make transmission likely is not known, but increased proportion translates into increased probability of transmission; thus, we focused on proportion of mutant virus in the total virus population.

Relatively subtle changes in the proportion of mutant mtDNA can lead to dramatic effects on a patient's phenotype; however, the mtDNA mutation doesn't do it alone.

In general, a threshold principle is evident where OXPHOS defects are expressed when the proportion of mutant mtDNA in a heteroplasmic cell is high.

Moreover, the imported oligoribonucleotide designed to target a pathogenic point mutation in mitochondrial DNA was able to induce a decrease in the proportion of mutant mitochondrial genomes.

The increasing proportion of mutant virus is only dependent on continued virus production and is independent of whether the virus load stays constant or declines (fig. S4) (21).

The variance in the proportion of mutant virus (Fig. 4, pale regions) increases with each additional mutation required because of the increased number of combinatorial options and the greater selective advantage of mutant viruses as compared with wild-type viruses in the hill-climb scenario.

Providing that the length of the flanking regions cloned into the recombinant plasmid is similar, the proportion of mutant and wild-type viruses should be similar.

Quantitative evaluation of E11.5 to E14.5 samples showed that the proportion of mutant PGCs with micronuclei increased slightly at 11.5 dpc, then dramatically from 12.5 to 14.5 dpc.