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The proportion of linkage disequilibrium was below that expected by chance.
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As a sensitivity analysis, the proportions of linkage among those born from 1969 to 1974 were calculated after excluding subjects with a missing given name (none among those born between 1961 and 1968).
The proportion of successful linkage varied by birth year, data source and linkage method.
The proportion of successful linkage was 77% with the Birth Registry, 70% with the Healthcare Registration File, 57% with both, and varied by birth year.
The proportion of identical linkage phases across breeding populations quickly declined with increasing physical distance between markers to values close to 0.5.
The proportion of identical linkage phases across breeding populations was considerably lower than 1 and quickly declined to values close to 0.5 with increasing marker distance.
Exact tests against Hardy Weinberg proportions and of linkage disequilibrium between pairs of loci were performed in genepop v.4.1 (Raymond and Rousset 1995).
Thus, the high proportion of functional linkages correlate directly with the mutant studies thus providing a rationale for the hypothesis that number of linkages is directly proportional to the essentiality of the gene.
Consequently, among those born from 1970 to 1974, much higher proportions of successful linkage of the electronic BCG Registry were achieved with the Birth Registry through probabilistic linkage, than with the Healthcare Registration File applying a deterministic approach.
Participants from both urban and rural areas had similar proportions of successful linkage to health insurance databases.
Figure 1 summarizes the data linkage process and overall proportions of record linkages.
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