STR also accounted for lower proportion of interruption by patient decision (1.5% vs. 11.8%, p = 0.01).
Moreover, excluding patients with IDU as risk factor (490 patients), a lower proportion of interruption was also detected (15.3% vs. 37.9%, p = 0.005) and finally, taking into account patients starting EFV-containing regimen from 2007 (since STR was available in Italy, 213 patients), still a significant lower proportion of interruption was observed (17.1% vs 34.1%, p = 0.03).
In contrast, STR accounted for significant lower proportion of interruption by patient decision: 1 in STR patients (1.5%, 95% CI: 0.0-3.0 0.0-3.0 (11.8%, 95% CI: 9.8-13.8),.
Further, the proportion of interruptions with personal content was significantly higher during low-severity (in case of an error as defined by nurses) tasks compared to medium- and high-severity tasks suggesting that other personnel may have evaluated the criticality of the nurses' tasks before interrupting.
The highest proportion of interruptions occurred when nurses were undertaking medication tasks (27.3%, n = 102), followed by documentation (23%, n = 86).
Kosit et al [ 32], in a study of interruptions in an emergency department, reported nurses were interrupted on average of 3.3 times per hour and that the highest proportion of interruptions (27%) occurred during medication tasks, as we found.
Although the sequence requirements for poly-pu/py-rich sequences to form secondary structures are not fully understood [ 52, 53, 56], the structures can tolerate a substantial proportion of interruptions to the homopurine/homopyrimidine motif [ 34, 36, 53], and can also be sensitive to single nucleotide changes [ 38, 39].
The overall proportion of EFV interruption was 37.4% at 4 years; at the same time point, interruptions for virological failure and toxicity were 8.8%andd 16.5% (8% for CNS-SE), respectively.
Starting EFV co-formulated in STR was associated with lower proportion of overall interruption at 4 years (17.1% vs. 40.6%, p < 0.01).
Excluding patients not treated with a tenofovir-containing backbone and then comparing STR vs. OD-2 pills regimens (tenofovir/emtricitabine as backbone) (249 patients), a lower proportion of treatment interruption in STR group was detected (17.1% vs 34.7%, p = 0.022) at survival analysis.
Abdominal surgical patients also had a higher proportion of feeding interruptions due to high gastric aspirates and starvation for procedures.
